272 Adiposis dolorosa and deoxycholic acid: An alternative therapeutic method

Dercum disease, or adiposis dolorosa, is a rare disorder characterized by multiple painful lipomas distributed throughout the body. There are currently no approved treatments for disease and excision often not feasible due to tumor burden extent of disease. Here we present use deoxycholic acid (DCA) reduce size associated with Ultrasound was used obtain 3-dimensional measurements in three patients. Lesions were identified treatment patient radiology input based on larger size, troublesome symptoms, feasibility location (e.g. accessibility injection avoidance critical structures). Controls chosen similar criteria symmetry within body lesions pain left vs right forearm). Imaging repeated, tracking changes treated untreated volumes calculated. The had 34% (patient 1), 68% 2), 41% 2) 30% 3) decrease volume, while control 111% 22% 93% increase volume. results show that all DCA reduction volume controls increased Interestingly, repeat imaging lipoma 3 revealed an anechoic center, possibly highlighting cell death adipocytes response injected DCA. naturally found assists emulsifying solubilizing fats. While initially as method submental fat, it may be possible alternative modality individuals extensive who candidates surgical excision. Additional studies should conducted determine appropriate dosing side effect profile.